Comparative study with ranitidine and cimetidine on gastric secretion.
نویسندگان
چکیده
The inihibitory effect of various doses of ranitidine and cimetidine on pentagastrin stimulated volume, acid, and pepsin secretion was studied in 8 healthy volunteers. Both compounds inhibited all three variables in a dose dependent manner with an average ID50 of approximately 5 mg for ranitidine and of approximately 41 mg for cimetidine. On a molar basis ranitidine is about 11 times more potent than cimetidine. The duration of action of both compounds appears to be equally long.
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ورودعنوان ژورنال:
- Gut
دوره 21 9 شماره
صفحات -
تاریخ انتشار 1980